Drug reference
pentosan polysulfate sodium
Drug monograph
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
—
none in our sources
PREGNANCY
—
not curated
Mechanism
The mechanism of action is unclear, but as a glycosaminoglycan, it is thought to help restore damaged urothelium, addressing a proposed etiologic factor of IC/BPS.
Indications
Interstitial Cystitis/Bladder Pain Syndrome (FDA-approved)
Side effects
Serious
- Vision-threatening maculopathy (association reported, causation not established)
Drug interactions
12 additional unreviewed or low-confidence interactions hidden because their provenance or source detail is insufficient.
Related guidelines
Empirical antimicrobial use in common syndromes
ICMR · Infectious Diseases · 2019
Acute coronary syndrome in chronic kidney disease
CSI · Cardiology · 2020
Sjögren's syndrome
EULAR · Rheumatology · 2025
Acute calculous cholecystitis
WSES · Surgery · 2020
Primary PCI for acute coronary syndrome
ESC · Cardiology · 2026
Other Unclassified drugs
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Textbook-sourced·Sources: Harrison 22e·Updated: 2026-05-10