Amisulpride
Severe
Database
Drug interaction classified as: antagonism
Source: DDInter
Drug reference
Pergolide
Dopamine Agonist · Antiparkinsonian
Also known as PERMAX
Dopamine AgonistAntiparkinsonian
CDSCO approvedSchedule H
EXCRETION
—
not curated
INTERACTIONS
4 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactions
- AmisulprideSevereDatabaseDDInter
- DextropropoxypheneSevereDatabaseDDInter
- LorcaserinSevereDatabaseDDInter
- Sodium OxybateSevereDatabaseDDInter
Mechanism
Pergolide is an ergot-derived dopamine-receptor agonist. It acts as a D1/D2 receptor agonist and is a nonselective compound that interacts with dopamine, 5-HT, and adrenergic receptors.
Indications
Monotherapy in Parkinson’s disease where dopamine-receptor agonists other than ergot derivative not appropriateAdjunctive therapy with co-beneldopa or co-careldopa in Parkinson’s disease where dopamine-receptor agonists other than ergot derivative not appropriate
Dosing
- Adult
- Monotherapy: Initially 50 micrograms once daily for day 1, dose to be taken at bedtime, then 50 micrograms twice daily for days 2–4, then increased in steps of 100–250 micrograms daily, dose to be increased at intervals of 3–4 days, increased to 1.5 mg daily in 3 divided doses at day 28, then increased in steps of up to 250 micrograms every 3–4 days, this increase to be started after day 30; maint…
- Max dose
- 3 mg per day
Contraindications
- Cardiac valvulopathy (exclude before treatment)
- History of fibrotic disorders
- Acute porphyrias
- Hypersensitivity to ergot alkaloids
Side effects
Common
Excessive sleepinessHallucinationsImpulse control disorders (including pathological gambling, binge eating, hypersexuality)
Serious
- Pulmonary fibrotic reactions
- Retroperitoneal fibrotic reactions
- Pericardial fibrotic reactions
- Cardiac valvulopathy
- Acute akinesia (with abrupt withdrawal)
- Neuroleptic malignant syndrome (with abrupt withdrawal)
Drug interactions
Dextropropoxyphene
Severe
Database
Clinical effect not specified
Source: DDInter
Lorcaserin
Severe
Database
Clinical effect not specified
Source: DDInter
Sodium Oxybate
Severe
Database
Clinical effect not specified
Source: DDInter
8 additional unreviewed or low-confidence interactions hidden because their provenance or source detail is insufficient.
Related guidelines
Other Dopamine Agonist drugs
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Textbook-sourced·Sources: Katzung, BNF·Updated: 2026-05-13