Drug reference

Quinagolide

Dopamine Agonist · Antihyperprolactinemic

Also known as Quinagolide hydrochloride, Norprolac

Dopamine AgonistAntihyperprolactinemic

CDSCO approvedSchedule H

EXCRETION

—

not curated

INTERACTIONS

—

none in our sources

PREGNANCY

Should not be used when pregnancy is intended due to data linking with fetal abnormalities.

FDA category + note

Mechanism

Quinagolide is a nonergot dopamine D2 receptor agonist. It acts in the pituitary to inhibit prolactin release by suppressing prolactin-secreting cells. This effective suppression leads to a decrease in circulating prolactin levels.

Indications

HyperprolactinemiaProlactin-secreting adenomas (prolactinomas)Reduction in size of prolactinomas

Dosing

Adult: 0.1 to 0.5 mg/day once daily.
Renal adjustment: Avoid (no information available)
Hepatic adjustment: Avoid (no information available)

Pharmacokinetics

Half-life

about 20 hours

Metabolism

Eliminated by metabolism

Contraindications

Pregnancy (not to be used when pregnancy is intended due to data linking with fetal abnormalities)
Should not be used when pregnancy is intended

Side effects

Common

Excessive daytime sleepinessSudden onset of sleepHypotensive reactions

Serious

Sudden onset of sleep (risk for driving or operating machinery)
Hypotensive reactions (particular care should be exercised when driving or operating machinery)