Drug reference

Phenindione

Anticoagulant

CDSCO approvedSchedule H

EXCRETION

—

not curated

INTERACTIONS

—

none in our sources

PREGNANCY

—

not curated

Mechanism

Phenindione is an oral anticoagulant classified as an indandione derivative. It acts as a vitamin K antagonist, thereby decreasing the functional levels of vitamin K-dependent clotting factors II, VII, and X.

Dosing

Adult: 16 Guidance on intravenous infusions

Pharmacokinetics

Half-life

5 hours

Side effects

Common

Taste alterationDecreased taste acuityOrange urineRashesFeverAlopecia

Serious

Serious hypersensitivity reactions (potentially fatal)
Leukopenia
Hepatitis
Nephropathy
Agranulocytosis
Serious organ toxicity (should not be used)

Related guidelines

GI bleeding on antiplatelet or anticoagulant therapy

CSI · Cardiology · 2020

Anticoagulant management for dental procedures

ADA_DENTAL · Dentistry · 2015

Venous thromboembolism prophylaxis

ASH · Haematology · 2018

Other Anticoagulant drugs

low-molecular-weight heparin

0 brands

Protamine

0 brands

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Sources: KD Tripathi 7e, BNF·Verified: 2026-05-10 · House clinical team