Drug reference

Protamine

Anticoagulant · Antidote for Anticoagulants

Also known as Protamine sulfate

AnticoagulantAntidote for Anticoagulants

CDSCO approvedSchedule H

EXCRETION

—

not curated

INTERACTIONS

—

none in our sources

PREGNANCY

—

not curated

Mechanism

Protamine sulfate acts as a specific antidote to unfractionated heparin by forming a stable ion pair, neutralizing its anticoagulant effects. It only partially reverses the effects of low molecular weight heparins.

Indications

Rapid reversal of unfractionated heparin effectsPartial reversal of low molecular weight heparin effectsNeutralization of heparin after procedures such as cardiopulmonary bypass

Dosing

Adult: Heparin reversal: 1 mg neutralises 80-100 units heparin (if given within 15 min of heparin). Max rate 5 mg/min. After heparin infusion: 25-50 mg IV once infusion stopped.
Max dose: 50 mg single dose