Undefined
Severe
Textbook
Haemorrhagic stroke.
Medicines containing PPA were banned.
Source: KDT 7e · p137
Drug reference
phenylpropanolamine
Sympathomimetic · Decongestant
SympathomimeticDecongestantATC R01AA04
CDSCO approvedATC R01AA04
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 12 →
- UndefinedSevereTextbookKDT 7e · p137
- BenzphetamineSevereDatabaseDDInter
- BromocriptineSevereDatabaseDDInter
- BupropionSevereDatabaseDDInter
Mechanism
Not yet extracted
Indications
nasal congestion (historical use)
Contraindications
- marketing in the U.S. no longer licensed (due to increased risk of hemorrhagic stroke)
Side effects
Serious
- hemorrhagic stroke
- Haemorrhagic stroke
- Behavioural/psychiatric disturbances
Drug interactions
Benzphetamine
Severe
Database
Clinical effect not specified
Source: DDInter
Bromocriptine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Bupropion
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Citalopram
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Desvenlafaxine
Severe
Database
Clinical effect not specified
Source: DDInter
Dexfenfluramine
Severe
Database
Clinical effect not specified
Source: DDInter
Diethylpropion
Severe
Database
Clinical effect not specified
Source: DDInter
Dihydroergotamine
Severe
Database
Clinical effect not specified
Source: DDInter
Duloxetine
Severe
Database
Clinical effect not specified
Source: DDInter
Ergometrine
Severe
Database
Clinical effect not specified
Source: DDInter
Ergotamine Tartrate
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Other Sympathomimetic drugs
Ask House about phenylpropanolamine
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Sources: KD Tripathi 7e, Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team