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pseudoephedrine

Sympathomimetic · Decongestant

SympathomimeticDecongestantATC R01BA02
CDSCO approvedATC R01BA02
EXCRETION
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
not curated
Top interactionssee all 12
  • DihydroergotamineSevereDatabaseDDInter
  • ErgometrineSevereDatabaseDDInter
  • Ergotamine TartrateSevereDatabaseDDInter
  • IsocarboxazidSevereDatabaseDDInter

Mechanism

Not yet extracted

Indications

nasal congestionDecongestant of upper respiratory tract, nose, and eustachian tubes

Dosing

Adult
30–60 mg TDS

Pharmacokinetics

Bioavailability
∼100%
Protein binding
Excretion
43–96%

Side effects

Serious
  • Rise in BP (especially in hypertensives)

Drug interactions

Dihydroergotamine
Severe
Database

Clinical effect not specified

Source: DDInter

Ergometrine
Severe
Database

Clinical effect not specified

Source: DDInter

Ergotamine Tartrate
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Isocarboxazid
Severe
Database

Clinical effect not specified

Source: DDInter

Linezolid
Severe
Database

Clinical effect not specified

Source: DDInter

Methylene Blue
Severe
Database

Clinical effect not specified

Source: DDInter

Methylergometrine
Severe
Database

Clinical effect not specified

Source: DDInter

Methysergide
Severe
Database

Clinical effect not specified

Source: DDInter

Ozanimod
Severe
Database

Clinical effect not specified

Source: DDInter

Phenelzine
Severe
Database

Clinical effect not specified

Source: DDInter

Procarbazine
Severe
Database

Clinical effect not specified

Source: DDInter

Selegiline
Severe
Database

Clinical effect not specified

Source: DDInter

Related guidelines

Other Sympathomimetic drugs

Ask House about pseudoephedrine

Continue into a citation-backed clinical answer with the drug context already attached.

Sources: KD Tripathi 7e, Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team