Adalimumab
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Drug reference
Polatuzumab vedotin
Monoclonal Antibody · Antineoplastic
Also known as Polivy
Monoclonal AntibodyAntineoplastic
CDSCO approvedSchedule H
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 12 →
- AdalimumabSevereDatabaseDDInter
- AmprenavirSevereDatabaseDDInter
- AtazanavirSevereDatabaseDDInter
- BaricitinibSevereDatabaseDDInter
Mechanism
Polatuzumab vedotin is a human IgG antibody-drug conjugate (ADC) that specifically targets CD79b on actively dividing B cells. Once internalized by the B cell, the microtubule-disrupting agent vedotin is released, causing cell death. This mechanism is similar to brentuximab vedotin.
Indications
Relapsed or treatment-refractory diffuse large B-cell lymphomas (DLBCL) in combination with bendamustine and a rituximab productrelapsed or refractory diffuse large B-cell lymphoma (in combination with bendamustine and rituximab)
Dosing
- Adult
- range of doses that are generally regarded as being suitable for adults. Complementary and alternative medicine Prescribing unlicensed medicines An increasing amount of information on complementary and alternative medicine is becoming available.…
Drug interactions
Amprenavir
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Atazanavir
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Baricitinib
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Boceprevir
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Ceritinib
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Certolizumab
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Cladribine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Clarithromycin
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Clozapine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Cobicistat
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Conivaptan
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Related guidelines
Blood transfusion in obstetrics and gynaecology
FOGSI · Obstetrics & Gynaecology · 2024
Pulmonary tuberculosis
RNTCP · Infectious Disease · 2023
Dyslipidaemia in diabetes
RSSDI · Endocrinology · 2022
Generalised anxiety disorder and panic disorder
NICE · Psychiatry · 2020
Hepatitis C — chronic infection
EASL · Gastroenterology · 2020
Other Monoclonal Antibody drugs
Ask House about Polatuzumab vedotin
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: Goodman & Gilman 14e, BNF·Verified: 2026-05-13 · House clinical team