rabies vaccine

Rabies vaccines contain inactivated rabies virus that induces an immune response. Specific types include: Antirabic vaccine carbolized (Neural tissue vaccine - NTV, 5% suspension of sheep brain substance with carbolic acid fixed rabies virus); Purified chick embryo cell vaccine (PCEV, Flury-LEP strain grown on chick fibroblasts, inactivated by β-propiolactone); Human diploid cell vaccine (HDCV, lyophilized inactivated rabies virus grown in human diploid cell culture); Purified vero cell rabies vaccine (PVRV, inactivated wistar rabies PM/WI38-1-503-3M strain grown on vero continuous cell line).

Adult

Post-exposure prophylaxis (non-immunized, Thai regimen): 0.1 ml of PCEV or PVRV or 0.2 ml of HDCV injected i.d. at 2 sites (over deltoid of both arms) on days 0, 3 and 7, followed by 1 site injection on day 28 (or 30) and day 90. Pre-exposure prophylaxis (Primary vaccination): Three i.d. injections of 0.1 ml each of PCEV/HDCV/PVRV on days 0, 7 and 28.…

Pediatric

Post-exposure prophylaxis (non-immunized, Thai regimen): 0.1 ml of PCEV or PVRV or 0.2 ml of HDCV injected i.d. at 2 sites (over deltoid of both arms) on days 0, 3 and 7, followed by 1 site injection on day 28 (or 30) and day 90.

• Cauterization with carbolic acid (for local wound treatment)
• Antirabic vaccine carbolized (Neural tissue vaccine) is obsolete and discontinued in India due to serious adverse effects.
• Gluteal injections (due to potential for vaccine failure)
• Administration with glucocorticoids or other immunosuppressive medications during PEP unless essential (may interfere with active immunity development).