Rocuronium
Mild
Textbook
Reverses rocuronium block within 3 min.
Source: KDT 7e · p355
Drug reference
sugamadex
Reversing agent (modified γ-cyclodextrin) · Antidote
Reversing agent (modified γ-cyclodextrin)Antidote
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
—
none in our sources
PREGNANCY
—
not curated
Mechanism
A modified γ-cyclodextrin with high affinity for rocuronium and vecuronium; encapsulates one molecule of the blocker within its molecule forming an inactive chelate. As the plasma concentration of free rocuronium falls, it rapidly dissociates from the Nm receptor and neuromuscular transmission is restored.
Indications
terminating the action of nondepolarizing muscle relaxants rocuronium and vecuronium
Pharmacokinetics
Half-life
~ 2 hours
Excretion
inactive chelate is excreted in urine
Side effects
Common
mild precordial painnauseaalteration of tasteallergy (rarely)
Drug interactions
Vecuronium
Mild
Textbook
Terminates the action of vecuronium.
Source: KDT 7e · p355
Related guidelines
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Sources: KD Tripathi 7e·Verified: 2026-05-10 · House clinical team