Drug reference

Sumatriptan

Triptan · Headache management

TriptanHeadache management

CDSCO approvedSchedule H

EXCRETION

—

not curated

INTERACTIONS

12 major

incl. contraindicated

PREGNANCY

Avoid unless potential beneﬁt outweighs risk.

FDA category + note

Top interactionssee all 12 →

ErgotamineContraindicatedTextbookKDT 7e · p179
MoclobemideContraindicatedTextbookG&G 14e · p293, p302
RasagilineContraindicatedTextbookG&G 14e · p293, p302
AlmotriptanSevereDatabaseDDInter

Mechanism

Sumatriptan is a 5HT1-receptor agonist. It is the 5HT1-receptor agonist of choice for acute migraine treatment based on its clinical efficacy and safety profile.

Indications

Treatment of cluster headache (subcutaneous injection)Acute migraine treatmentCombination therapy with naproxen for acute migraine in patients who fail monotherapyManagement of severe migraine attacks or early vomiting in migraine (subcutaneous administration)Treatment of cluster headache (nasal spray, off-label)Acute treatment of migraine

Dosing

Adult: ▶ BY MOUTH l INTERACTIONS 6.1 Headache 22-Feb-2018 The properties listed below are those particular to the combination only. For the properties of the components please consider, paracetamol p. 465, tramadol hydrochloride p. 491. l INDICATIONS AND DOSE Moderate to severe pain Cluster headache rarely responds to standard analgesics. Sumatriptan p.…
Renal adjustment: Reduce dose in renal impairment
Hepatic adjustment: Reduce dose in hepatic impairment

Pharmacokinetics

Bioavailability

PO: 14 ± 5%; SC: 97 ± 16%

Protein binding

14–21%

Excretion

22 ± 4%

Contraindications

Ischemic heart disease
Coronary artery vasospasm
Exposure to MAO inhibitor within preceding 2 weeks
Within 24 hours of another triptan
Within 24 hours of an ergot derivative
Within 24 hours of SSRIs
Within 24 hours of SNRIs

Side effects

Common

DizzinessSomnolenceNeck painChest painParesthesiasAstheniaFatigueFlushingFeelings of pressure/tightnessNauseaSweatingInjection site irritation (transient mild pain, stinging, or burning sensations with subcutaneous injection)Bitter taste (with nasal spray)

Serious