Frovatriptan

Frovatriptan is a selective 5-HT1D/1B receptor agonist that interacts potently with 5-HT1B and 5-HT1D receptors. Its antimigraine effects are thought to be mediated by agonism at these receptors, leading to vasoconstriction of dilated cranial vessels and a reduction in neurogenic inflammation and plasma leakage in the duramater. This action decreases the pain associated with migraine.

Adult

Isometheptene mucate 65 mg, Paracetamol 325 mg Midrid. 325mg/65mg capsules | 30 capsule P £7.50 DT = £7.50. Metoclopramide hydrochloride 10 mg, Aspirin DL-Lysine. 900 mg MigraMax oral powder sachets sugar-free | 6 sachet P. Metoclopramide hydrochloride 5 mg, Paracetamol

Renal adjustment

Reduce dose in renal impairment

Hepatic adjustment

Reduce dose in hepatic impairment

• Ischemic heart disease
• Coronary artery vasospasm
• Within 24 hours of another triptan
• Within 24 hours of an ergot derivative
• Within 24 hours of SSRIs
• Within 24 hours of SNRIs