Drug reference

Telenzepine

Antimuscarinic · Antiulcer Agent

AntimuscarinicAntiulcer Agent

CDSCO approvedSchedule H

EXCRETION

—

not curated

INTERACTIONS

—

none in our sources

PREGNANCY

—

not curated

Mechanism

Telenzepine is an M1 muscarinic receptor antagonist, structurally an analog of pirenzepine, with higher potency and similar M1 selectivity. It acts as an inverse agonist, shifting muscarinic receptors to an inactive state to prevent acetylcholine binding and subsequent effects like inositol trisphosphate (IP3) release and adenylyl cyclase inhibition. Telenzepine suppresses neural stimulation of gastric acid production by acting on M1 receptors located in intramural ganglia.

Indications

Acid-peptic diseasePeptic ulcer diseasePeptic ulcer disease (used in Europe, Japan, and Canada, not in the U.S.)

Dosing

Adult: In the doses usually used, atropine has minimal stimulant effects on the CNS, especially the parasympathetic medullary centers, and a slower, longer lasting sedative effect on the brain. Scopolamine has more marked central effects, producing drowsiness when given in recommended dosages and amnesia in sensitive individuals that may be mediated via the histamine H3 receptor.…