Drug reference
thioguanine
Thiopurine drug
Thiopurine drug
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
—
none in our sources
PREGNANCY
—
not curated
Mechanism
Not yet extracted
Indications
Acute myeloid leukemiahuman leukemiasChildhood acute leukaemiaSome solid tumours
Pharmacokinetics
Metabolism
Undergoes S-methylation catalyzed by thiopurine methyltransferase (TPMT) for detoxification.
Contraindications
- Genetic deficiency in thiopurine methyltransferase (TPMT) (risk of severe toxicities)
Side effects
Common
Hyperuricaemia
Serious
- Bone marrow depression
Related guidelines
Other Unclassified drugs
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Textbook-sourced·Sources: KD Tripathi 7e, Goodman & Gilman 14e·Updated: 2026-05-10