Duloxetine
Contraindicated
Database
CYP2D6 inhibition increases levels of these drugs; QT prolongation risk
Avoid combination
Source: Kimi deep-research + Cla
Drug reference
thioridazine
Phenothiazine antipsychotic · Antipsychotic
Phenothiazine antipsychoticAntipsychotic
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
incl. contraindicated
PREGNANCY
—
not curated
Top interactionssee all 12 →
- DuloxetineContraindicatedDatabaseKimi deep-research + Cla
- FluoxetineContraindicatedDatabaseDDInter
- FlupenthixolContraindicatedDatabase
- ParoxetineContraindicatedDatabaseDDInter
Mechanism
Not yet extracted
Indications
Agitated patients with schizophreniaCombative patients with schizophreniaViolent patients with schizophreniaPatients where extrapyramidal side effects must be avoided
Side effects
Common
brown pigmentary deposits in the cornea, conjunctiva, and eyelidsSignificant antimuscarinic effects
Serious
- Retinal degeneration
Drug interactions
Fluoxetine
Contraindicated
Database
Increased risk of QTc prolongation, ventricular arrhythmias (e.g., Torsades de Pointes), and sudden cardiac death.
CONTRAINDICATED. Do not co-administer. A washout period of at least 5 weeks is required after discontinuing fluoxetine before starting thioridazine.
Source: DDInter
Flupenthixol
Contraindicated
Database
Significantly increased risk of severe QTc prolongation and potentially fatal arrhythmias (e.g., Torsades de Pointes). Both are potent QTc prolonging agents.
Concomitant use is contraindicated due to high risk of severe cardiac adverse events.
Paroxetine
Contraindicated
Database
Increased risk of serious ventricular arrhythmias (e.g., Torsades de Pointes) and sudden death.
Concomitant use is contraindicated. A washout period is required when switching between these drugs.
Source: DDInter
Abarelix
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Abiraterone
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Adenosine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Alfentanil
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Alfuzosin
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Alimemazine
Severe
Database
Drug interaction classified as: synergy, metabolism
Source: DDInter
Aminolevulinic Acid
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Amiodarone
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Related guidelines
Ask House about thioridazine
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: KD Tripathi 7e, Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team