Digitalis Glycosides
Severe
Textbook
Increased digitalis-induced arrhythmias.
Not explicitly stated, but implies careful monitoring of potassium levels.
Source: G&G 14e · p566
Drug reference
Torasemide
Loop Diuretic · Diuretic, Antihypertensive
Loop DiureticDiuretic, Antihypertensive
CDSCO approvedSchedule H
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
Manufacturer advises avoid—toxicity in animal studies.
FDA category + note
Top interactionssee all 12 →
- Digitalis GlycosidesSevereTextbookG&G 14e · p566
- PaclitaxelSevereTextbookG&G 14e · p566
- AmikacinSevereDatabaseDDInter
- AminoglycosidesSevereDatabase
Mechanism
Torasemide is a high-efficacy loop diuretic that primarily acts in the thick ascending limb of the loop of Henle. It inhibits the Na+-K+-2Cl- cotransporter (NKCC2), thereby blocking the reabsorption of these ions. This action significantly increases the excretion of sodium, chloride, and water, leading to potent diuresis and natriuresis, and consequently, increased potassium excretion due to the higher sodium load presented to the distal tubules.
Indications
OedemaHypertensionEdema
Dosing
- Adult
- Oedema: 5 mg once daily, to be taken preferably in the morning, then increased if necessary to 20 mg once daily. Hypertension: 2.5 mg daily, then increased if necessary to 5 mg once daily.
- Max dose
- 40 mg per day
Pharmacokinetics
Duration
4–8 hours
Half-life
3.5 hours
Side effects
Common
AstheniaGastrointestinal disorderBladder dilationUrinary retention
Serious
- Allergic dermatitis
- Anaemia
- Cerebral ischaemia
- Confusion
- Dry mouth
- Embolism
- Ischaemic heart disease
- Myocardial infarction
- Pancreatitis
- Syncope
- Visual impairment
Pregnancy & lactation
Pregnancy
Manufacturer advises avoid—toxicity in animal studies.
Lactation
Manufacturer advises avoid—no information available.
Drug interactions
Paclitaxel
Severe
Textbook
Increased risk of ototoxicity (e.g., tinnitus, hearing impairment, deafness, vertigo).
Not explicitly stated, but implies careful monitoring or avoidance if possible.
Source: G&G 14e · p566
Amikacin
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Aminoglycosides
Severe
Database
Increased risk of ototoxicity (e.g., tinnitus, hearing impairment, deafness, vertigo).
Not explicitly stated, but implies careful monitoring or avoidance if possible.
Aminolevulinic Acid
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Amiodarone
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Arsenic Trioxide
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Cisapride
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Cisplatin
Severe
Database
Enhanced ototoxicity.
Not explicitly stated, but implies careful monitoring or avoidance if possible.
Source: DDInter
Desmopressin
Severe
Database
Clinical effect not specified
Source: DDInter
Dofetilide
Severe
Database
Clinical effect not specified
Source: DDInter
Dolasetron
Severe
Database
Clinical effect not specified
Source: DDInter
Related guidelines
Other Loop Diuretic drugs
Ask House about Torasemide
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: KD Tripathi 7e, Katzung·Verified: 2026-05-10 · House clinical team