Drug reference

Aminocaproic Acid

Hemostatic

Also known as Amicar, ε-aminocaproic acid

Hemostatic

CDSCO approvedSchedule H

EXCRETION

—

not curated

INTERACTIONS

3 major

SEVERE in our sources

PREGNANCY

—

not curated

Top interactionssee all 4 →

Anti Inhibitor Coagulant ComplexSevereDatabaseDDInter
CarfilzomibSevereDatabaseDDInter
TretinoinSevereDatabaseDDInter

Mechanism

Aminocaproic acid is an inhibitor of fibrinolysis. It prevents plasminogen from binding to fibrin, thereby inhibiting its activation to plasmin. This action helps stabilize fibrin clots and reduce bleeding by preventing the degradation of fibrin.

Indications

Oral bleedingreduce bleeding after prostatic surgeryreduce bleeding after tooth extractions in patients with hemophiliareduce intraoperative bleedingprevention or treatment of mucosal bleedingprophylaxis for dental proceduresadjunctive therapy with DDAVP or factor concentrate for dental extractions, tonsillectomies, and prostate proceduresBleeding in the gumsGastrointestinal tract bleedingBleeding during oral surgery

Dosing

Adult: clotbound. However, this regulatory system is overwhelmed by therapeutic doses of plasminogen activators. If the coagulation and fibrinolytic systems are pathologically activated, the hemostatic system may careen out of control, leading to generalized intravascular clotting and bleeding.…

Pharmacokinetics

Onset

absorbed rapidly after oral administration

Excretion

50% excreted unchanged in the urine within 12 h

Contraindications

ureteral obstruction by clots in patients with hematuria
upper urinary tract bleeding due to the risk of ureteral obstruction
Control of hematuria (due to concern for forming an occlusive clot in the lumen of genitourinary tract structures)