Benazepril
Moderate
Database
Icatibant was investigated for treating ACE inhibitor–associated angioedema but was shown to lack clinical utility.
Icatibant is not effective for treating ACE inhibitor–induced angioedema.
Source: DDInter
Drug reference
Icatibant
Hemostatic · Drugs Used in Hereditary Angioedema
Also known as HOE-140, Firazyr, Icatibant acetate
HemostaticDrugs Used in Hereditary Angioedema
CDSCO approvedSchedule H
EXCRETION
—
not curated
INTERACTIONS
—
none in our sources
PREGNANCY
Manufacturer advises use only if potential benefit outweighs risk—toxicity in animal studies.
FDA category + note
Mechanism
Icatibant is a selective bradykinin B2 receptor antagonist. It blocks signaling mediated by B2 receptors, which can be activated by kinin generation or directly by certain proteases like kallikrein.
Indications
Acute attacks of hereditary angioedema in patients with C1-esterase inhibitor deficiencyAcute attacks of hereditary angioedema (HAE) in adults, adolescents and children aged 2 years and older, with C1 esterase-inhibitor deficiencySymptomatic treatment of hereditary angioedema
Dosing
- Adult
- 30 mg for 1 dose, then 30 mg after 6 hours if required, then 30 mg after 6 hours if required; maximum 3 doses per day by subcutaneous injection
- Max dose
- 90 mg per day
Pharmacokinetics
Half-life
Longer t½ (resistant to kinin degrading enzymes)
Side effects
Common
DizzinessFeverHeadacheNauseaSkin reactions
Pregnancy & lactation
Pregnancy
Manufacturer advises use only if potential benefit outweighs risk—toxicity in animal studies.
Lactation
Manufacturer advises avoid for 12 hours after administration.
Drug interactions
Captopril
Moderate
Database
Icatibant was investigated for treating ACE inhibitor–associated angioedema but was shown to lack clinical utility.
Icatibant is not effective for treating ACE inhibitor–induced angioedema.
Source: DDInter
Enalapril
Moderate
Database
Icatibant was investigated for treating ACE inhibitor–associated angioedema but was shown to lack clinical utility.
Icatibant is not effective for treating ACE inhibitor–induced angioedema.
Source: DDInter
Fosinopril
Moderate
Database
Icatibant was investigated for treating ACE inhibitor–associated angioedema but was shown to lack clinical utility.
Icatibant is not effective for treating ACE inhibitor–induced angioedema.
Source: DDInter
Lisinopril
Moderate
Database
Icatibant was investigated for treating ACE inhibitor–associated angioedema but was shown to lack clinical utility.
Icatibant is not effective for treating ACE inhibitor–induced angioedema.
Source: DDInter
Moexipril
Moderate
Database
Icatibant was investigated for treating ACE inhibitor–associated angioedema but was shown to lack clinical utility.
Icatibant is not effective for treating ACE inhibitor–induced angioedema.
Source: DDInter
Perindopril
Moderate
Database
Icatibant was investigated for treating ACE inhibitor–associated angioedema but was shown to lack clinical utility.
Icatibant is not effective for treating ACE inhibitor–induced angioedema.
Source: DDInter
Quinapril
Moderate
Database
Icatibant was investigated for treating ACE inhibitor–associated angioedema but was shown to lack clinical utility.
Icatibant is not effective for treating ACE inhibitor–induced angioedema.
Source: DDInter
Ramipril
Moderate
Database
Icatibant was investigated for treating ACE inhibitor–associated angioedema but was shown to lack clinical utility.
Icatibant is not effective for treating ACE inhibitor–induced angioedema.
Source: DDInter
Trandolapril
Moderate
Database
Icatibant was investigated for treating ACE inhibitor–associated angioedema but was shown to lack clinical utility.
Icatibant is not effective for treating ACE inhibitor–induced angioedema.
Source: DDInter
Enalaprilat
Mild
Textbook
Icatibant was investigated for treating ACE inhibitor–associated angioedema but was shown to lack clinical utility.
Icatibant is not effective for treating ACE inhibitor–induced angioedema.
Source: G&G 14e
Related guidelines
Iron deficiency anaemia in adults
ICMR · Hematology · 2023
Iron deficiency anaemia in pregnancy
ICMR · Obstetrics & Gynaecology · 2022
Iron deficiency anaemia in pregnancy
FOGSI · Obstetrics & Gynaecology · 2017
Acute diarrhoea in children
IAP · Pediatrics · 2022
Heart failure in diabetes
RSSDI · Cardiology · 2023
Other Hemostatic drugs
Ask House about Icatibant
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: KD Tripathi 7e, Goodman & Gilman 14e, Katzung, BNF·Verified: 2026-05-10 · House clinical team