antacids

Reduced ledipasvir concentrations, potentially leading to treatment failure/relapse.

If antacids must be used, separate administration by 4 hours. Follow specific dosing instructions for H2 blockers (max 40 mg famotidine BID) and PPIs (max 20 mg omeprazole QD, administered simultaneously with LDV/SOF in fasted state).

Source: G&G 14e · p1238, p1242

Reduced velpatasvir concentrations, potentially leading to treatment failure.

Antacids should be separated by 4 hours. Velpatasvir requires acidic gastric pH.

Source: G&G 14e · p1239, p1242

Decreased absorption and efficacy of the bisphosphonate.

Oral bisphosphonates should be administered with a full glass of water following an overnight fast and at least 30 min before breakfast to avoid interaction with divalent cations.

Source: G&G 14e · p1060

May affect the dissolution, absorption, bioavailability, and renal elimination of allopurinol.

Take antacids 2 hours before or after ingestion of other drugs.

Source: G&G 14e · p1079

Decreased plasma levels of azoles.

Source: Harrison 22e · p1742

Reduced plasma levels and potential loss of efficacy of baloxavir.

Avoid taking baloxavir with antacids.

Source: Harrison 22e · unknown

Decreased absorption of cimetidine, reducing its efficacy.

When used concurrently, a gap of 2 hr should be allowed.

Source: KDT 7e · p650

Reduced dasatinib bioavailability.

Source: G&G 14e · p1396

Decreased absorption of diazepam.

Stagger administration of antacids and diazepam by 2 hours.

Source: KDT 7e · p656

Decreased absorption of ethambutol.

Stagger administration of antacids and ethambutol by 2 hours.

Source: KDT 7e · p656

Decreased absorption of fluoroquinolones.

Stagger administration of antacids and fluoroquinolones by 2 hours.

Source: KDT 7e · p656

Decreased absorption of H2 blockers.

Stagger administration of antacids and H2 blockers by 2 hours.

Source: KDT 7e · p656