Bictegravir
Severe
Database
Drug interaction classified as: absorption
Source: DDInter
Drug reference
Magnesium hydroxide
Antacid · Antacid, Laxative
Also known as Phillips’ Milk of Magnesia, Magnesium Hydroxide Mixture, BP
AntacidAntacid, LaxativeATC A06AD01
CDSCO approvedATC A06AD01
EXCRETION
—
not curated
INTERACTIONS
7 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 12 →
- BictegravirSevereDatabaseDDInter
- DolutegravirSevereDatabaseDDInter
- ErdafitinibSevereDatabaseDDInter
- PatiromerSevereDatabaseDDInter
Mechanism
Magnesium hydroxide acts as an antacid by neutralizing gastric acid. It also exhibits a laxative effect, contributing to the relief of constipation.
Indications
ConstipationDyspepsiaGastro-oesophageal reflux diseaseConstipation (cathartic effect)AntacidComponent in antacid combinations
Dosing
- Adult
- 30–45 mL as required, dose to be given mixed with water at bedtime
- Pediatric
- Child 3–11 years: 5–10 mL as required, dose to be given mixed with water at bedtime. Child 12–17 years: 30–45 mL as required, dose to be given mixed with water at bedtime
- Renal adjustment
- Avoid or reduce dose due to increased risk of toxicity
- Hepatic adjustment
- Avoid in hepatic coma if risk of renal failure
Contraindications
- Acute gastro-intestinal conditions
- Debilitated patients
- Elderly patients
- Hepatic coma if risk of renal failure
- Renal impairment (increased risk of toxicity)
- Renal insufficiency
- Cardiac disease
- Preexisting electrolyte abnormalities
- Patients on diuretic therapy
Side effects
Common
ConstipationDiarrhoeaAbdominal painDiarrhea (dose related)Laxative action
Serious
- Electrolyte imbalance
- Toxicity in renal impairment
- Hypermagnesemia (in patients with impaired renal function)
- Problematic absorption if renal function is inadequate
Drug interactions
Dolutegravir
Severe
Database
Clinical effect not specified
Source: DDInter
Erdafitinib
Severe
Database
Drug interaction classified as: others
Source: DDInter
Patiromer
Severe
Database
Clinical effect not specified
Source: DDInter
Raltegravir
Severe
Database
Clinical effect not specified
Source: DDInter
Selpercatinib
Severe
Database
Clinical effect not specified
Source: DDInter
Tolevamer
Severe
Database
Clinical effect not specified
Source: DDInter
Ciprofloxacin
Moderate
Textbook-cited
Therapeutic failure of the antibiotic.
Stagger administration by 2-3 hours
Source: KDT 7e · p949
Doxycycline
Moderate
Textbook-cited
Therapeutic failure of the antibiotic.
Stagger administration by 2-3 hours
Source: KDT 7e · p949
Levofloxacin
Moderate
Textbook-cited
Therapeutic failure of the antibiotic.
Stagger administration by 2-3 hours
Source: KDT 7e · p949
Minocycline
Moderate
Textbook-cited
Therapeutic failure of the antibiotic
Stagger administration by 2-3 hours
Source: KDT 7e · p949
Moxifloxacin
Moderate
Textbook-cited
Therapeutic failure of the antibiotic.
Stagger administration by 2-3 hours
Source: KDT 7e · p949
Related guidelines
Gastro-oesophageal reflux disease
ISG · Gastroenterology · 2022
Coeliac disease
OTHER · Gastroenterology · 2016
Inflammatory bowel disease
OTHER · Gastroenterology · 2015
Preventive care in inflammatory bowel disease
ACG · Gastroenterology · 2025
Chronic kidney disease — assessment and management
KDIGO · Nephrology · 2024
Other Antacid drugs
Ask House about Magnesium hydroxide
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: KD Tripathi 7e, Goodman & Gilman 14e, Katzung, BNF·Verified: 2026-05-10 · House clinical team