Adrenaline
Severe
Textbook
Marked rise in BP.
Adrenaline should not be given to patients receiving β blockers.
Source: KDT 7e · p133
Drug reference
Betaxolol
Beta Blocker · Antiglaucoma agent
Beta BlockerAntiglaucoma agentATC S01ED02
CDSCO approvedSchedule HATC S01ED02
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
Beta-blockers may cause intra-uterine
FDA category + note
Top interactionssee all 12 →
- AdrenalineSevereTextbookKDT 7e · p133
- AmilorideSevereTextbookKDT 7e
- SofosbuvirSevereTextbookHarrison 22e · unknown
- AminophyllineSevereDatabaseDDInter
Mechanism
Betaxolol is a β1-selective adrenergic receptor antagonist that competitively blocks β1-adrenoceptors, primarily in the heart. This action inhibits the Gs protein-mediated increase in intracellular cyclic AMP (cAMP) typically induced by catecholamines. The clinical consequence is a reduction in heart rate and myocardial contractility, leading to a decrease in cardiac output and blood pressure.
Indications
GlaucomaOcular hypertensionChronic open-angle glaucomaSuspected chronic open-angle glaucomahypertensionangina pectorisGlaucoma (topical)
Dosing
- Adult
- administration by intravenous injection, excessive bradycardia can occur and may be countered with intravenous injection of atropine sulfate. Overdose Therapeutic overdosages with beta-blockers may cause lightheadedness, dizziness, and possibly syncope as a result of bradycardia and hypotension; heart failure may be precipitated or exacerbated.…
Pharmacokinetics
Half-life
14 to 22 h
Bioavailability
high
Contraindications
- abrupt discontinuation (withdrawal syndrome)
Side effects
Common
mild and transient side effectsTransient stinging (ocular)Burning (ocular)Less bronchopulmonary, cardiac, central and metabolic side effects compared to nonselective beta blockers
Serious
- life-threatening bradyarrhythmias (with AV conduction defects or other drugs)
- exacerbation of angina (abrupt discontinuation)
- increased risk of sudden death (abrupt discontinuation)
- blunted recognition/delayed recovery from hypoglycemia
Pregnancy & lactation
Pregnancy
Beta-blockers may cause intra-uterine
Drug interactions
Amiloride
Severe
Textbook
Hyperkalaemia more likely.
Source: KDT 7e
Sofosbuvir
Severe
Textbook
Severe bradycardia.
Extreme caution advised if amiodarone is co-administered with sofosbuvir and a beta blocker.
Source: Harrison 22e · unknown
Aminophylline
Severe
Database
Drug interaction classified as: antagonism
Source: DDInter
Atazanavir
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Ceritinib
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Clonidine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Diltiazem
Severe
Database
Increased propensity for AV block, severe bradycardia, and decreased left ventricular function.
Avoid concurrent administration. The concurrent administration of diltiazem with a beta blocker is contraindicated.
Source: DDInter
Disopyramide
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Dolasetron
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Dyphylline
Severe
Database
Drug interaction classified as: antagonism
Source: DDInter
Fingolimod
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Related guidelines
Other Beta Blocker drugs
Ask House about Betaxolol
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: KD Tripathi 7e, Goodman & Gilman 14e, BNF·Verified: 2026-05-13 · House clinical team