Increased propensity for AV block, severe bradycardia, and decreased left ventricular function.
Avoid concurrent administration. The concurrent administration of diltiazem with a beta blocker is contraindicated.
Source: G&G 14e · p617
Beta Blocker · Antihypertensive
Bucindolol is a nonselective beta-adrenergic receptor antagonist with additional capacity to block alpha-1 adrenergic receptors. Beta-receptor blockade reduces sympathetic activity on the heart. Alpha-1 receptor blockade inhibits vasoconstriction induced by endogenous catecholamines, leading to vasodilation, decreased peripheral resistance, and a subsequent fall in blood pressure.
Increased propensity for AV block, severe bradycardia, and decreased left ventricular function.
Avoid concurrent administration. The concurrent administration of diltiazem with a beta blocker is contraindicated.
Source: G&G 14e · p617
Reduced efficacy of ritodrine and potential for adverse cardiovascular effects.
Ritodrine should not be used if the mother is receiving beta blockers.
Source: KDT 7e · p333
Marked rise in BP.
Adrenaline should not be given to patients receiving β blockers.
Source: KDT 7e · p133
Hyperkalaemia more likely.
Source: KDT 7e
Severe hypertension and cerebral hemorrhage.
The use of epinephrine generally is contraindicated in patients who are receiving nonselective β receptor antagonists.
Source: G&G 14e · p258
Exaggerated or prolonged bronchoconstriction and reduction in vital capacity in response to methacholine.
Emergency resuscitation equipment, oxygen, and medications to treat severe bronchospasm (e.g., β2 adrenergic receptor agonists for inhalation) should be available during testing.
Source: G&G 14e · p212
Severe bradycardia.
Extreme caution advised if amiodarone is co-administered with sofosbuvir and a beta blocker.
Source: Harrison 22e · unknown
Hyperkalaemia more likely.
Source: KDT 7e
Life-threatening bradyarrhythmias.
Particular caution is indicated.
Source: G&G 14e · p275
Reduced antihypertensive effect.
Monitor blood pressure and consider alternative antihypertensive agents or NSAIDs if necessary.
Source: G&G 14e · p275
Reduced antihypertensive effect.
Monitor blood pressure and consider alternative antihypertensive agents or NSAIDs if necessary.
Source: G&G 14e · p275
Increased antihypertensive effect.
This combination is often used to achieve better blood pressure control and manage reflex tachycardia from alpha-1 blockers.
Source: G&G 14e
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: Goodman & Gilman 14e, Katzung·Verified: 2026-05-13 · House clinical team