Carbocisteine

Carbocisteine is a mucolytic agent that is believed to reduce sputum viscosity. This action facilitates the removal of secretions from the respiratory tract by coughing, thereby improving airway clearance.

Adult

Initially 2.25 g daily in divided doses, then reduced to 1.5 g daily in divided doses, as condition improves

Renal adjustment

Avoid if eGFR less than 25 mL/minute/1.73 m2

Hepatic adjustment

Caution in mild to moderate hepatic failure; avoid in severe hepatic failure. Max. 300 mg daily in mild to moderate hepatic failure.

Max dose

2.25 g daily

• Active peptic ulceration
• History of peptic ulceration (may disrupt the gastric mucosal barrier)
• Peptic ulcer patients (may break gastric mucosal barrier)