Drug reference

Cetrorelix

GnRH Analogue · Infertility treatment

Also known as Cetrorelix acetate

GnRH AnalogueInfertility treatment

CDSCO approved

EXCRETION

—

not curated

INTERACTIONS

—

none in our sources

PREGNANCY

Avoid in confirmed pregnancy.

FDA category + note

Mechanism

Cetrorelix is a luteinising hormone releasing hormone antagonist. It works by inhibiting the release of gonadotrophins, namely luteinising hormone and follicle stimulating hormone, which are essential for ovulation.

Indications

Adjunct in the treatment of female infertility (initiated under specialist supervision)Infertility by assisted reproductive techniquesSuppression of the LH surge to prevent premature ovulation in ovarian-stimulation protocols as part of assisted reproduction technologyEndometriosis (off-label)Uterine fibroids (off-label)controlled ovarian hyperstimulation (IVF protocols)Inhibiting LH surges during controlled ovarian stimulation in women undergoing in vitro fertilization

Dosing

Adult: By subcutaneous injection: 250 micrograms once daily, administered in the morning, starting on day 5 or 6 of ovarian stimulation with gonadotrophins (or each evening starting on day 5 of ovarian stimulation). Continue throughout administration of gonadotrophin including day of ovulation induction (or evening before ovulation induction).…
Renal adjustment: Avoid in moderate or severe renal impairment.
Hepatic adjustment: Manufacturer advises use with cautionno information available.