Drug reference
Gonadorelin
GnRH Analogue · Diagnostic Agent
Also known as Gonadotrophin-releasing hormone, GnRH, LH–RH, Gonadorelin hydrochloride
GnRH AnalogueDiagnostic Agent
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
—
none in our sources
PREGNANCY
Avoid.
FDA category + note
Mechanism
Gonadorelin is an endogenous gonadotrophin-releasing hormone (GnRH). It directly stimulates the anterior pituitary gland to release gonadotrophins, specifically luteinising hormone (LH) and follicle-stimulating hormone (FSH). This mechanism is utilized to assess pituitary function.
Indications
Assessment of pituitary functionTesting pituitary-gonadal axis in male hypogonadismTesting pituitary-gonadal axis in female hypogonadism
Dosing
- Adult
- 100 micrograms for 1 dose by subcutaneous or intravenous injection for assessment of pituitary function.
Pharmacokinetics
Half-life
4–8 min (due to rapid enzymatic degradation)
Contraindications
- Ovarian cysts (not caused by polycystic ovarian syndrome)
- Ovarian enlargement (not caused by polycystic ovarian syndrome)
- Tumours of breast
- Tumours of hypothalamus
- Tumours of ovaries
- Tumours of pituitary
- Tumours of prostate
- Tumours of testes
- Tumours of uterus
- Vaginal bleeding of unknown cause
Side effects
Common
PainSkin reactionsSwellingDizzinessEye erythemaFlushingHeadacheNauseaTachycardia
Serious
- Abdominal discomfort
- Bronchospasm
- Menorrhagia
- Sepsis
- Thrombophlebitis
Pregnancy & lactation
Pregnancy
Avoid.
Lactation
Avoid.
Related guidelines
Coronary angiography with renal dysfunction
CSI · Cardiology · 2020
Functional (psychogenic non-epileptic) seizures
AAN · Neurology · 2026
Chronic kidney disease — assessment and management
KDIGO · Nephrology · 2024
Chronic kidney disease — assessment and management
NICE · Nephrology · 2021
Irritable bowel syndrome
ISG · Gastroenterology · 2023
Other GnRH Analogue drugs
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Sources: KD Tripathi 7e, Katzung, BNF·Verified: 2026-05-10 · House clinical team