Drug reference

Danazol

GnRH Analogue · Endometriosis treatment; Fibrocystic breast disease treatment; Hereditary angioedema prophylaxis

GnRH AnalogueEndometriosis treatment; Fibrocystic breast disease treatment; Hereditary angioedema prophylaxis

CDSCO approvedSchedule H

EXCRETION

—

not curated

INTERACTIONS

12 major

SEVERE in our sources

PREGNANCY

Most manufacturers of antihistamines advise

FDA category + note

Top interactionssee all 12 →

AnisindioneSevereDatabaseDDInter
AtorvastatinSevereDatabaseDDInter
CarfilzomibSevereDatabaseDDInter
CerivastatinSevereDatabaseDDInter

Mechanism

:null

Indications

EndometriosisRelief of severe pain and tenderness in benign fibrocystic breast disease where other measures have proved unsatisfactoryLong-term prophylaxis of hereditary angioedema (off-label)Short-term prophylaxis of hereditary angioedema before planned procedures (e.g., dental work) (off-label)endometriosis therapy (rarely used now)treatment of hereditary angioedemamenorrhagiafibrocystic breast disease (chronic cystic mastitis)hereditary angioneurotic edema

Dosing

Adult: acute attacks of hereditary angioedema in adults with C1-esterase inhibitor deﬁciency. Tranexamic acid p. 117 and danazol p. 783 [unlicensed indication] are used for short-term and long-term prophylaxis of hereditary angioedema. Short-term prophylaxis with tranexamic acid or danazol is started several days before planned procedures (e.g. dental work) and continued for 2–5 days afterwards.…

Pharmacokinetics

Half-life

12–18 hours

Contraindications

Children (due to androgenic effects)

Side effects

Common

Androgenic effectshirsutismelevation of hepatic transaminasescomplete amenorrhoea (with higher doses)acnedecreased breast sizedeepening of voiceedemaweight gainloss of libido (in men)hot flashes (in women)night sweatsmuscle crampsg.i. upsetelevation of hepatic enzymes

Serious