Drug reference

Cyclizine

Antihistamine · Antiemetic

Also known as Cyclizine hydrochloride, Cyclizine lactate

AntihistamineAntiemetic

CDSCO approvedSchedule H

EXCRETION

—

not curated

INTERACTIONS

6 major

SEVERE in our sources

PREGNANCY

—

not curated

Top interactionssee all 6 →

DextropropoxypheneSevereDatabaseDDInter
Potassium ChlorideSevereDatabaseDDInter
Potassium CitrateSevereDatabaseDDInter
Sodium OxybateSevereDatabaseDDInter

Mechanism

Cyclizine is a first-generation antihistamine with anticholinergic (antimuscarinic) properties. It acts centrally in the brain by blocking H1-receptors and muscarinic receptors. This action helps to suppress vestibular stimulation and reduce the sensitivity of the chemoreceptor trigger zone, thereby alleviating nausea and vomiting, particularly that associated with motion sickness and mechanical bowel obstruction.

Indications

Nausea and vomiting due to mechanical bowel obstructionNausea and vomiting due to raised intracranial pressureMotion sickness

Dosing

Adult: Dose changes Changes in dose statements that appear in the print edition of BNF 80 (September 2020—March 2021): . Benzoin tincture, compound p. 313 [updated child age range]. . Betamethasone with clioquinol p. 1314 [updated child age range]. Co-ﬂuampicil p. 582 [update to dosing information]. Ergotamine tartrate with caffeine hydrate and cyclizine hydrochloride p. 500 [addition of max. courses...