Adalimumab
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Drug reference
Dinutuximab
Monoclonal Antibody · Antineoplastic agent
Monoclonal AntibodyAntineoplastic agent
CDSCO approvedSchedule H
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
and reproductive function in Cytotoxic drugs
FDA category + note
Top interactionssee all 12 →
- AdalimumabSevereDatabaseDDInter
- BaricitinibSevereDatabaseDDInter
- BeclomethasoneSevereDatabaseDDInter
- BetamethasoneSevereDatabaseDDInter
Mechanism
Dinutuximab is a chimeric monoclonal antibody that specifically targets the carbohydrate moiety of disialoganglioside 2 (GD2), which is overexpressed on neuroblastoma cells. This binding initiates the destruction of neuroblastoma tumor cells and is often used in combination with immunomodulatory agents.
Indications
High-risk neuroblastoma (in combination with granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin 2 (IL-2), and 13-cis-retinoic acid (RA) for patients who achieve at least a partial response to prior first-line multiagent, multimodality therapy)neuroblastoma (in combination with GM-CSF, IL-2, and retinoic acid)
Dosing
- Adult
- l INDICATIONS AND DOSE High-risk neuroblastoma (specialist use only) ▶ BY INTRAVENOUS INFUSION ▶ Adult: (consult product literature) Acute grade 3 or 4, or extensive chronic graft-versus-host disease l CAUTIONS Avoid vaccinations during and for at least 10 weeks after treatment cessation (increased risk of immune stimulation and neurological toxicity) .…
Side effects
Common
Infusion reactionsNeurotoxicity
Serious
- Serious infusion reactions
- Neurotoxicity
- infusion reaction
- nerve damage
Pregnancy & lactation
Pregnancy
and reproductive function in Cytotoxic drugs
Drug interactions
Baricitinib
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Beclomethasone
Severe
Database
Clinical effect not specified
Source: DDInter
Betamethasone
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Budesonide
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Certolizumab
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Ciclesonide
Severe
Database
Clinical effect not specified
Source: DDInter
Cladribine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Clozapine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Deferiprone
Severe
Database
Clinical effect not specified
Source: DDInter
Deflazacort
Severe
Database
Clinical effect not specified
Source: DDInter
Dexamethasone
Severe
Database
Clinical effect not specified
Source: DDInter
Related guidelines
Other Monoclonal Antibody drugs
Ask House about Dinutuximab
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: Goodman & Gilman 14e, BNF·Verified: 2026-05-13 · House clinical team