Drug reference

Docusate

Laxative · Constipation

Also known as Dioctyl sodium sulphosuccinate, Dioctyl sodium sulfosuccinate, DOSS, docusate sodium, docusate calcium

LaxativeConstipationATC A06AA02

CDSCO approvedATC A06AA02

EXCRETION

—

not curated

INTERACTIONS

—

none in our sources

PREGNANCY

—

not curated

Mechanism

Docusate salts are anionic surfactants that lower the surface tension of the stool, allowing mixing of aqueous and fatty substances, thereby softening the stool and permitting easier defecation. These agents also stimulate intestinal fluid and electrolyte secretion, possibly by increasing mucosal cyclic AMP, and alter intestinal mucosal permeability. By a detergent action, docusate emulsifies colonic contents, increases water penetration into faeces, and can disrupt the mucosal barrier.

Indications

Chronic constipationAdjunct in abdominal radiological proceduresWhen straining at stools must be avoided

Dosing

Adult: Oral: Up to 500 mg daily in divided doses, adjusted according to response. Rectal: 120 mg for 1 dose; as enema 50–150 mg in 50–100 ml. For abdominal radiological procedures: 400 mg orally, to be administered with barium meal.
Pediatric: Child 6–23 months: 12.5 mg 3 times a day, adjusted according to response, use paediatric oral solution. Child 2–11 years: 12.5–25 mg 3 times a day, adjusted according to response, use paediatric oral solution. Child 12–17 years: Oral: Up to 500 mg daily in divided doses, adjusted according to response. Rectal: 120 mg for 1 dose.
Max dose: 500 mg daily (oral)