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Glycerol

Laxative · Constipation

LaxativeConstipation
CDSCO approvedSchedule H
EXCRETION
not curated
INTERACTIONS
none in our sources
PREGNANCY
and breast-feeding
FDA category + note

Mechanism

Glycerol suppositories act as a lubricant and a rectal stimulant due to the mildly irritant action of glycerol. They also possess faecal softening properties by decreasing surface tension and increasing the penetration of intestinal fluid into the faecal mass.

Indications

ConstipationReduce intraocular or intracranial tension

Dosing

Adult
treatment of chronic constipation in adults, when other laxatives have failed to provide an adequate response.…

Contraindications

  • Intestinal obstruction

Side effects

Common
Abdominal crampRectal irritation
Serious
  • Hypokalaemia (with laxative abuse)
  • Haemolysis (with intravenous administration)

Pregnancy & lactation

Pregnancy

and breast-feeding

Related guidelines

Other Laxative drugs

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Sources: KD Tripathi 7e, BNF·Verified: 2026-05-13 · House clinical team