Drug reference
Glycerol
Laxative · Constipation
LaxativeConstipation
CDSCO approvedSchedule H
EXCRETION
—
not curated
INTERACTIONS
—
none in our sources
PREGNANCY
and breast-feeding
FDA category + note
Mechanism
Glycerol suppositories act as a lubricant and a rectal stimulant due to the mildly irritant action of glycerol. They also possess faecal softening properties by decreasing surface tension and increasing the penetration of intestinal fluid into the faecal mass.
Indications
ConstipationReduce intraocular or intracranial tension
Dosing
- Adult
- treatment of chronic constipation in adults, when other laxatives have failed to provide an adequate response.…
Contraindications
- Intestinal obstruction
Side effects
Common
Abdominal crampRectal irritation
Serious
- Hypokalaemia (with laxative abuse)
- Haemolysis (with intravenous administration)
Pregnancy & lactation
Pregnancy
and breast-feeding
Related guidelines
Other Laxative drugs
Ask House about Glycerol
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Sources: KD Tripathi 7e, BNF·Verified: 2026-05-13 · House clinical team