Indomethacin
Moderate
Textbook
Reduced purgative action of senna.
Source: KDT 7e · p675
Drug reference
Senna
Laxative
LaxativeATC A06AB06
CDSCO approvedSchedule HATC A06AB06
EXCRETION
—
not curated
INTERACTIONS
—
none in our sources
PREGNANCY
advice on the use of a drug during pregnancy
FDA category + note
Mechanism
Senna, an anthraquinone stimulant laxative, increases intestinal motility. It is believed to act by increasing the activity of NO synthase and the biosynthesis of platelet-activating factor in the gut, which stimulates colonic secretion and GI motility. Nitric oxide (NO) may also contribute by stimulating intestinal secretion and inhibiting segmenting contractions in the colon, thereby promoting laxation.
Indications
ConstipationOpioid-induced constipation (prevention)Constipation in cancer patients
Dosing
- Adult
- Indication and dose User feedback has highlighted that one of the main uses of the BNF is identifying indications and doses of drugs. Therefore, indication and dose information has been promoted to the top of the monograph and highlighted by a coloured panel to aid quick reference.…
Pharmacokinetics
Onset
6 to 12 h
Contraindications
- Intestinal obstruction
Side effects
Common
Abdominal crampToleranceNauseaVomitingAbdominal cramping
Serious
- Hypokalaemia (with laxative abuse)
- Melanosis coli (with chronic use)
Pregnancy & lactation
Pregnancy
advice on the use of a drug during pregnancy
Drug interactions
Related guidelines
Other Laxative drugs
Ask House about Senna
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: Goodman & Gilman 14e, Harrison 22e, BNF·Verified: 2026-05-13 · House clinical team