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Drug reference

etidronate

Bisphosphonate · Antiresorptive agent

BisphosphonateAntiresorptive agent
CDSCO approved
EXCRETION
not curated
INTERACTIONS
none in our sources
PREGNANCY
not curated

Mechanism

Not yet extracted

Indications

Paget diseaseheterotopic ossificationhypercalcemiaHypercalcaemiaPaget’s diseaseHumoral Hypercalcemia of Malignancy

Dosing

Adult
5–7.5 mg/kg/day

Pharmacokinetics

Bioavailability
6%

Contraindications

  • abnormalities that delay esophageal emptying
  • Gastroesophageal reflux
  • Peptic ulcer
  • Renal impairment (general BPN contraindications)

Side effects

Common
heartburnesophageal irritationesophagitisabdominal paindiarrheaGastric irritation
Serious
  • nephrotoxicity
  • osteonecrosis of the jaw
  • esophageal ulcers
  • esophageal erosions
  • Osteomalacia (with continuous therapy)

Related guidelines

Other Bisphosphonate drugs

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Sources: KD Tripathi 7e, Goodman & Gilman 14e, Harrison 22e·Verified: 2026-05-10 · House clinical team