Drug reference

Parathyroid hormone

Bisphosphonate · Hormone replacement therapy

Also known as Human recombinant parathyroid hormone, rhPTH 1-84

BisphosphonateHormone replacement therapy

CDSCO approvedSchedule H

EXCRETION

—

not curated

INTERACTIONS

2 major

SEVERE in our sources

PREGNANCY

—

not curated

Top interactions

DigitoxinSevereDatabaseDDInter
DigoxinSevereDatabaseDDInter

Mechanism

Parathyroid hormone is produced by recombinant DNA technology. Endogenous parathyroid hormone modulates serum calcium and phosphate levels, regulates renal calcium and phosphate excretion, activates vitamin D, and maintains normal bone turnover. It is a single-chain peptide hormone that regulates calcium and phosphate flux across cellular membranes in bone and kidney, resulting in increased serum calcium and decreased serum phosphate by increasing the activity of osteoblasts and osteoclasts.

Indications

Chronic hypoparathyroidism (specialist use only)

Dosing

Adult: Consult product literature. Administered by subcutaneous injection.

Pharmacokinetics

Half-life

rapid, with a half-time of disappearance measured in minutes

Metabolism

Most of the clearance occurs in the liver and kidney.

Excretion

Most of the clearance occurs in the liver and kidney.

Contraindications

Bone metastases
Current or previous radiation therapy to skeleton
Increased risk factors for osteosarcoma (including Paget's disease or hereditary disorders)
Pseudohypoparathyroidism
Skeletal malignancy
Unexplained raised levels of bone-specific alkaline phosphatase
Concomitant use of cardiac glycosides (hypercalcaemia may predispose to digitalis toxicity)