Drug reference

Glatiramer acetate

Immunosuppressant · Multiple sclerosis treatment

Also known as GA, COPAXONE

ImmunosuppressantMultiple sclerosis treatment

CDSCO approved

EXCRETION

—

not curated

INTERACTIONS

1 major

SEVERE in our sources

PREGNANCY

—

not curated

Top interactions

NatalizumabSevereDatabaseDDInter

Mechanism

Glatiramer acetate is a synthetic polypeptide that binds efficiently to MHC class II DR molecules. While its precise mechanism of immunomodulation in multiple sclerosis is not fully understood, studies suggest it induces highly cross-reactive CD4+ T cells to secrete Th2 cytokines. This action is thought to downregulate the immune response to myelin antigens and activate suppressive T cells that migrate to the central nervous system.

Indications

Relapsing-remitting multiple sclerosisRapidly-evolving severe relapsing-remitting multiple sclerosisrelapsing-remitting ms (decreasing exacerbations by ~30%)prevents the appearance of new lesions detectable by magnetic resonance imaging