Aspirin
Severe
Textbook-cited
Hypoglycemia.
Avoid concurrent use; substitute with paracetamol if analgesic needed
Source: KDT 7e · p949
Drug reference
Glibenclamide
Sulfonylurea · Antidiabetic
Also known as Glyburide, DIABETA
SulfonylureaAntidiabetic
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 12 →
- AspirinSevereTextbook-citedKDT 7e · p949
- AtazanavirSevereTextbook-citedKDT 7e · p948
- CarbamazepineSevereTextbook-citedKDT 7e · p949
- CelecoxibSevereTextbook-citedKDT 7e · p949
Mechanism
Sulfonylureas stimulate insulin release by binding to a specific site on the β cell KATP channel complex (the sulfonylurea receptor, SUR) and inhibiting its activity. KATP channel inhibition causes cell membrane depolarization and the cascade of events leading to insulin secretion. The acute administration of sulfonylureas to type 2 diabetes patients increases insulin release from the pancreas and may reduce hepatic clearance of insulin, further increasing plasma insulin levels.
Indications
Treatment of type 2 diabetes mellitustype-2 diabetes mellitustype 2 diabetes mellitus
Dosing
- Adult
- 1.25-20 mg orally daily (standard formulation); 0.75-12 mg orally daily (micronized formulation). A typical dose mentioned is 5 mg twice daily.
- Geriatric
- Should be avoided altogether.
- Max dose
- 20 mg (standard formulation); 12 mg (micronized formulation)
Pharmacokinetics
Duration
12-24 hours
Half-life
2–4 hours
Protein binding
>90%
Metabolism
Metabolized in liver
Excretion
Excreted in urine
Contraindications
- Avoid altogether in elderly patients
- pregnancy (change to insulin advised)
- nursing mothers
- liver dysfunction
- kidney dysfunction
Side effects
Common
Hypoglycemia (symptoms include anxiety, sweating, palpitation, weakness, ataxia)hypoglycaemia (higher incidence)weight gain (1-3 kg)nauseavomitingflatulencediarrhoeaconstipationheadacheparesthesias
Serious
- Severe hypoglycemia
- disulfiram-like reaction after alcohol
- rashes
- photosensitivity
- purpura
- transient leukopenia
- agranulocytosis (rare)
Pregnancy & lactation
Lactation
Secreted in milk; should not be given to nursing mothers
Drug interactions
Atazanavir
Severe
Textbook-cited
Hypoglycemia.
Avoid concurrent use or adjust dose
Source: KDT 7e · p948
Carbamazepine
Severe
Textbook-cited
Loss of glycemic control; hyperglycemia.
Increase sulfonylurea dose or switch to non-interacting agent
Source: KDT 7e · p949
Celecoxib
Severe
Textbook-cited
Hypoglycemia.
Avoid concurrent use; substitute with paracetamol if analgesic needed
Source: KDT 7e · p949
Chloramphenicol
Severe
Textbook-cited
Hypoglycemia
Monitor blood glucose; reduce sulfonylurea dose
Source: KDT 7e · p949
Clarithromycin
Severe
Textbook-cited
Hypoglycemia.
Avoid concurrent use or adjust dose
Source: KDT 7e · p948
Cotrimoxazole
Severe
Textbook-cited
Hypoglycemia
Avoid concurrent use; if needed, monitor blood glucose closely
Source: KDT 7e · p948
Darunavir
Severe
Textbook-cited
Hypoglycemia
Avoid concurrent use or adjust dose
Source: KDT 7e · p948
Diclofenac
Severe
Textbook-cited
Hypoglycemia.
Avoid concurrent use; substitute with paracetamol if analgesic needed
Source: KDT 7e · p949
Erythromycin
Severe
Textbook-cited
Hypoglycemia.
Avoid concurrent use or adjust dose
Source: KDT 7e · p948
Fluconazole
Severe
Textbook-cited
Hypoglycemia.
Avoid concurrent use or adjust dose
Source: KDT 7e · p948
Ibuprofen
Severe
Textbook-cited
Hypoglycemia.
Avoid concurrent use; substitute with paracetamol if analgesic needed
Source: KDT 7e · p949
Related guidelines
Gestational diabetes mellitus
FOGSI · Obstetrics & Gynaecology · 2023
Fluid and electrolyte management in diabetes
RSSDI · Endocrinology · 2025
Diabetes management during Ramadan
ADA · Endocrinology · 2025
Vaccination in adults with diabetes
RSSDI · Endocrinology · 2024
Glucose monitoring in diabetes
RSSDI · Endocrinology · 2024
Other Sulfonylurea drugs
Ask House about Glibenclamide
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: KD Tripathi 7e, Katzung, BNF·Verified: 2026-05-10 · House clinical team