Bosentan
Contraindicated
Textbook
Not explicitly detailed, but implied significant adverse effects.
Coadministration with glyburide is contraindicated.
Source: G&G 14e · p702
Drug reference
glyburide
Sulfonylurea · Antidiabetic agent
SulfonylureaAntidiabetic agent
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
1 major
incl. contraindicated
PREGNANCY
—
not curated
Top interactionssee all 2 →
- BosentanContraindicatedTextbookG&G 14e · p702
Mechanism
Glyburide stimulates insulin release by binding to a specific site on the β cell KATP channel complex (SUR) and inhibiting its activity. This KATP channel inhibition causes cell membrane depolarization and a cascade of events leading to insulin secretion.
Indications
Hyperglycemia in type 2 diabetes
Pharmacokinetics
Half-life
3-5 h
Bioavailability
G: 90–100%; M: 64–90%
Protein binding
90%-99% bound to protein, especially albumin
Metabolism
Liver
Excretion
Negligible
Side effects
Common
HypoglycemiaWeight gain (1-3 kg)NauseaVomiting
Serious
- Coma (due to hypoglycemia)
- Cholestatic jaundice
- Agranulocytosis
- Aplastic anemia
- Hemolytic anemia
- Generalized hypersensitivity reactions
- Dermatological reactions
- Alcohol-induced flush
- Hyponatremia
Drug interactions
Colesevelam
Moderate
Textbook
Altered plasma levels and efficacy of glyburide, potentially affecting glycemic control.
Source: G&G 14e · p1041
Related guidelines
Gestational diabetes mellitus
FOGSI · Obstetrics & Gynaecology · 2023
Fluid and electrolyte management in diabetes
RSSDI · Endocrinology · 2025
Diabetes management during Ramadan
ADA · Endocrinology · 2025
Vaccination in adults with diabetes
RSSDI · Endocrinology · 2024
Glucose monitoring in diabetes
RSSDI · Endocrinology · 2024
Other Sulfonylurea drugs
Ask House about glyburide
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team