Angiotensin Receptor Blockers
Severe
Textbook
Greater incidence of acute kidney injury (AKI) and adverse cardiac events.
The combination of these two classes should be avoided.
Source: Harrison 22e · p2396
Drug reference
imidapril
ACE inhibitor · Antihypertensive, Heart failure agent, Cardioprotective agent, Renoprotective agent
ACE inhibitorAntihypertensive, Heart failure agent, Cardioprotective agent, Renoprotective agent
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 12 →
- Angiotensin Receptor BlockersSevereTextbookHarrison 22e · p2396
- AzilsartanSevereTextbookHarrison 22e · p2396
- Azilsartan MedoxomilSevereTextbookHarrison 22e · p2396
- CandesartanSevereTextbookHarrison 22e · p2396
Mechanism
Imidapril is a long-acting prodrug ACE inhibitor. After absorption and conversion to its active form, it inhibits Angiotensin Converting Enzyme (ACE), preventing the conversion of Angiotensin I to Angiotensin II, thereby reducing Ang II's vasoconstrictive and aldosterone-stimulating effects. It also increases plasma kinin levels by inhibiting ACE's kininase activity, contributing to vasodilation.
Indications
HypertensionCongestive heart failure (CHF)Myocardial infarction (MI)Prophylaxis in high cardiovascular risk subjectsDiabetic nephropathyNondiabetic nephropathyScleroderma crisis
Pharmacokinetics
Peak effect
6–8 hr
Half-life
> 24 hr
Bioavailability
40% (reduced by meals)
Drug interactions
Azilsartan
Severe
Textbook
Greater incidence of acute kidney injury (AKI) and adverse cardiac events.
The combination of these two classes should be avoided.
Source: Harrison 22e · p2396
Azilsartan Medoxomil
Severe
Textbook
Greater incidence of acute kidney injury (AKI) and adverse cardiac events.
The combination of these two classes should be avoided.
Source: Harrison 22e · p2396
Candesartan
Severe
Textbook
Greater incidence of acute kidney injury (AKI) and adverse cardiac events.
The combination of these two classes should be avoided.
Source: Harrison 22e · p2396
Eprosartan
Severe
Textbook
Greater incidence of acute kidney injury (AKI) and adverse cardiac events.
The combination of these two classes should be avoided.
Source: Harrison 22e · p2396
Irbesartan
Severe
Textbook
Greater incidence of acute kidney injury (AKI) and adverse cardiac events.
The combination of these two classes should be avoided.
Source: Harrison 22e · p2396
Losartan
Severe
Textbook
Greater incidence of acute kidney injury (AKI) and adverse cardiac events.
The combination of these two classes should be avoided.
Source: Harrison 22e · p2396
Losartan + Hydrochlorothiazide
Severe
Textbook
Greater incidence of acute kidney injury (AKI) and adverse cardiac events.
The combination of these two classes should be avoided.
Source: Harrison 22e · p2396
Olmesartan
Severe
Textbook
Greater incidence of acute kidney injury (AKI) and adverse cardiac events.
The combination of these two classes should be avoided.
Source: Harrison 22e · p2396
Olmesartan + Amlodipine
Severe
Textbook
Greater incidence of acute kidney injury (AKI) and adverse cardiac events.
The combination of these two classes should be avoided.
Source: Harrison 22e · p2396
Olmesartan + Hydrochlorothiazide
Severe
Textbook
Greater incidence of acute kidney injury (AKI) and adverse cardiac events.
The combination of these two classes should be avoided.
Source: Harrison 22e · p2396
Olmesartan Medoxomil
Severe
Textbook
Greater incidence of acute kidney injury (AKI) and adverse cardiac events.
The combination of these two classes should be avoided.
Source: Harrison 22e · p2396
Related guidelines
Other ACE inhibitor drugs
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Textbook-sourced·Sources: KD Tripathi 7e·Updated: 2026-05-10