Angiotensin Receptor Blockers
Severe
Textbook
Greater incidence of acute kidney injury (AKI) and adverse cardiac events.
The combination of these two classes should be avoided.
Source: Harrison 22e · p2396
Drug reference
angiotensin-converting enzyme inhibitors
ACE inhibitor
ACE inhibitor
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 12 →
- Angiotensin Receptor BlockersSevereTextbookHarrison 22e · p2396
- AzilsartanSevereTextbookHarrison 22e · p2396
- Azilsartan MedoxomilSevereTextbookHarrison 22e · p2396
- CandesartanSevereTextbookHarrison 22e · p2396
Mechanism
Reduces ventricular remodeling after infarction, leading to a subsequent reduction in the risk of heart failure. May also lower the rate of recurrent infarction.
Indications
Reduce mortality rate after STEMI (additive to aspirin and beta blockers)High-risk patients (anterior infarction, prior infarction, globally depressed LV function)Hemodynamically stable patients with STEMI (systolic pressure >100 mmHg)Patients with clinically evident heart failurePatients with reduced global LV function or large regional wall motion abnormalityHypertensive patientsLong-term prevention of ventricular remodeling and recurrent ischemic events
Drug interactions
Azilsartan
Severe
Textbook
Greater incidence of acute kidney injury (AKI) and adverse cardiac events.
The combination of these two classes should be avoided.
Source: Harrison 22e · p2396
Azilsartan Medoxomil
Severe
Textbook
Greater incidence of acute kidney injury (AKI) and adverse cardiac events.
The combination of these two classes should be avoided.
Source: Harrison 22e · p2396
Candesartan
Severe
Textbook
Greater incidence of acute kidney injury (AKI) and adverse cardiac events.
The combination of these two classes should be avoided.
Source: Harrison 22e · p2396
Eprosartan
Severe
Textbook
Greater incidence of acute kidney injury (AKI) and adverse cardiac events.
The combination of these two classes should be avoided.
Source: Harrison 22e · p2396
Irbesartan
Severe
Textbook
Greater incidence of acute kidney injury (AKI) and adverse cardiac events.
The combination of these two classes should be avoided.
Source: Harrison 22e · p2396
Losartan
Severe
Textbook
Greater incidence of acute kidney injury (AKI) and adverse cardiac events.
The combination of these two classes should be avoided.
Source: Harrison 22e · p2396
Losartan + Hydrochlorothiazide
Severe
Textbook
Greater incidence of acute kidney injury (AKI) and adverse cardiac events.
The combination of these two classes should be avoided.
Source: Harrison 22e · p2396
Olmesartan
Severe
Textbook
Greater incidence of acute kidney injury (AKI) and adverse cardiac events.
The combination of these two classes should be avoided.
Source: Harrison 22e · p2396
Olmesartan + Amlodipine
Severe
Textbook
Greater incidence of acute kidney injury (AKI) and adverse cardiac events.
The combination of these two classes should be avoided.
Source: Harrison 22e · p2396
Olmesartan + Hydrochlorothiazide
Severe
Textbook
Greater incidence of acute kidney injury (AKI) and adverse cardiac events.
The combination of these two classes should be avoided.
Source: Harrison 22e · p2396
Olmesartan Medoxomil
Severe
Textbook
Greater incidence of acute kidney injury (AKI) and adverse cardiac events.
The combination of these two classes should be avoided.
Source: Harrison 22e · p2396
Related guidelines
Other ACE inhibitor drugs
Ask House about angiotensin-converting enzyme inhibitors
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: Harrison 22e·Verified: 2026-05-10 · House clinical team