Drug reference
lercanidipine
Dihydropyridine calcium channel blocker · Antihypertensive; Calcium channel blocker
Dihydropyridine calcium channel blockerAntihypertensive; Calcium channel blocker
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
—
none in our sources
PREGNANCY
—
not curated
Mechanism
Lercanidipine lowers blood pressure by relaxing arteriolar smooth muscle and decreasing peripheral vascular resistance through inhibition of transmembrane movement of Ca2+ via voltage-sensitive Ca2+ channels. This action reduces the total amount of Ca2+ that reaches intracellular sites, leading to vasodilation.
Indications
Hypertension
Dosing
- Adult
- 10–20 mg OD
Pharmacokinetics
Peak effect
1.5–3 hrs
Half-life
5–10 hours
Side effects
Common
Peripheral edema (ankle edema)
Related guidelines
Other Dihydropyridine calcium channel blocker drugs
Ask House about lercanidipine
Continue into a citation-backed clinical answer with the drug context already attached.
Textbook-sourced·Sources: KD Tripathi 7e, Goodman & Gilman 14e·Updated: 2026-05-10