Apalutamide
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Drug reference
levamlodipine
Dihydropyridine calcium channel blocker · Antihypertensive; Calcium channel blocker
Dihydropyridine calcium channel blockerAntihypertensive; Calcium channel blocker
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 12 →
- ApalutamideSevereDatabaseDDInter
- CarbamazepineSevereDatabaseDDInter
- CeritinibSevereDatabaseDDInter
- DolasetronSevereDatabaseDDInter
Mechanism
Lowers blood pressure by relaxing arteriolar smooth muscle and decreasing peripheral vascular resistance through inhibition of transmembrane movement of Ca2+ via voltage-sensitive Ca2+ channels. This action reduces the total amount of Ca2+ that reaches intracellular sites, leading to vasodilation.
Drug interactions
Carbamazepine
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Ceritinib
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Dolasetron
Severe
Database
Clinical effect not specified
Source: DDInter
Enzalutamide
Severe
Database
Clinical effect not specified
Source: DDInter
Fosphenytoin
Severe
Database
Clinical effect not specified
Source: DDInter
Itraconazole
Severe
Database
Clinical effect not specified
Source: DDInter
Lumacaftor
Severe
Database
Clinical effect not specified
Source: DDInter
Mitotane
Severe
Database
Clinical effect not specified
Source: DDInter
Phenobarbital
Severe
Database
Clinical effect not specified
Source: DDInter
Phenytoin
Severe
Database
Clinical effect not specified
Source: DDInter
Primidone
Severe
Database
Clinical effect not specified
Source: DDInter
Related guidelines
Other Dihydropyridine calcium channel blocker drugs
Ask House about levamlodipine
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team