Isocarboxazid
Severe
Textbook
Increased risk of adverse cardiovascular effects.
At least 2 weeks should elapse between the use of MAO inhibitors and administration of β2 agonists or other sympathomimetics.
Source: G&G 14e · p264
Drug reference
levalbuterol
β2-selective adrenergic receptor agonist (R-enantiomer of albuterol) · Bronchodilator
β2-selective adrenergic receptor agonist (R-enantiomer of albuterol)BronchodilatorATC R03AC13
CDSCO approvedATC R03AC13
EXCRETION
—
not curated
INTERACTIONS
7 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 9 →
- IsocarboxazidSevereTextbookG&G 14e · p264
- MoclobemideSevereTextbookG&G 14e · p264
- PhenelzineSevereTextbookG&G 14e · p264
- ProcarbazineSevereTextbookG&G 14e · p264
Mechanism
Levalbuterol is the R-enantiomer of albuterol, acting as a β2-selective agonist to relax bronchial smooth muscle.
Indications
asthmaCOPD
Pharmacokinetics
Bioavailability
similar pharmacokinetic properties to albuterol
Side effects
Common
Muscle tremorTachycardiaPalpitations
Serious
- Hypokalemia
- Ventilation-perfusion (V/Q) mismatch (fall in arterial oxygen tension)
- Metabolic effects (increase in free fatty acid, insulin, glucose, pyruvate, and lactate)
Drug interactions
Moclobemide
Severe
Textbook
Increased risk of adverse cardiovascular effects.
At least 2 weeks should elapse between the use of MAO inhibitors and administration of β2 agonists or other sympathomimetics.
Source: G&G 14e · p264
Phenelzine
Severe
Textbook
Increased risk of adverse cardiovascular effects.
At least 2 weeks should elapse between the use of MAO inhibitors and administration of β2 agonists or other sympathomimetics.
Source: G&G 14e · p264
Procarbazine
Severe
Textbook
Increased risk of adverse cardiovascular effects.
At least 2 weeks should elapse between the use of MAO inhibitors and administration of β2 agonists or other sympathomimetics.
Source: G&G 14e · p264
Rasagiline
Severe
Textbook
Increased risk of adverse cardiovascular effects.
At least 2 weeks should elapse between the use of MAO inhibitors and administration of β2 agonists or other sympathomimetics.
Source: G&G 14e · p264
Selegiline
Severe
Textbook
Increased risk of adverse cardiovascular effects.
At least 2 weeks should elapse between the use of MAO inhibitors and administration of β2 agonists or other sympathomimetics.
Source: G&G 14e · p264
Tranylcypromine
Severe
Textbook
Increased risk of adverse cardiovascular effects.
At least 2 weeks should elapse between the use of MAO inhibitors and administration of β2 agonists or other sympathomimetics.
Source: G&G 14e · p264
Corticosteroids
Moderate
Textbook
Enhanced beneficial effects in asthma therapy for both drugs.
Source: G&G 14e · p887
Digoxin
Moderate
Textbook
Hypokalemia, which could predispose to cardiac arrhythmias, especially in patients with cardiac disease.
Use with caution.
Source: G&G 14e · p264
Related guidelines
Ask House about levalbuterol
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Sources: Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team