Alfentanil
Severe
Database
Drug interaction classified as: others
Source: DDInter
Drug reference
Methylene blue
Antidote · Antidote for Methemoglobinemia
AntidoteAntidote for Methemoglobinemia
CDSCO approvedSchedule H
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
No information available, but risk to fetus of
FDA category + note
Top interactionssee all 12 →
- AlfentanilSevereDatabaseDDInter
- AlmotriptanSevereDatabaseDDInter
- AmitriptylineSevereDatabaseDDInter
- AmoxapineSevereDatabaseDDInter
Mechanism
The mechanism of action is not detailed in the provided textbook excerpts, but it acts as an antidote for methemoglobinemia.
Indications
MethemoglobinemiaSymptomatic acquired methemoglobinemia (with 40–60% methemoglobin)
Dosing
- Adult
- l INDICATIONS AND DOSE Drug- or chemical-induced methaemoglobinaemia ▶ BY SLOW INTRAVENOUS INJECTION ▶ Child 3 months–17 years: Initially 1–2 mg/kg, then 1–2 mg/kg after 30–60 minutes if required, to be given over 5 minutes, seek advice from National Poisons Information Service if further repeat doses are required; maximum 7 mg/kg per course ▶ Adult: Initially 1–2 mg/kg, then 1–2 mg/kg after 30–60…
Pregnancy & lactation
Pregnancy
No information available, but risk to fetus of
Drug interactions
Almotriptan
Severe
Database
Clinical effect not specified
Source: DDInter
Amitriptyline
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Amoxapine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Amphetamine
Severe
Database
Clinical effect not specified
Source: DDInter
Apraclonidine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Atomoxetine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Benzhydrocodone
Severe
Database
Drug interaction classified as: others
Source: DDInter
Benzphetamine
Severe
Database
Clinical effect not specified
Source: DDInter
Buprenorphine
Severe
Database
Drug interaction classified as: others
Source: DDInter
Bupropion
Severe
Database
Drug interaction classified as: synergy.
Source: DDInter
Buspirone
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Related guidelines
Other Antidote drugs
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Continue into a citation-backed clinical answer with the drug context already attached.
Sources: Harrison 22e, BNF·Verified: 2026-05-13 · House clinical team