Amprenavir
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Drug reference
Naloxegol
Antidote · Gastrointestinal Agent
AntidoteGastrointestinal AgentATC A06AH02
CDSCO approvedSchedule HATC A06AH02
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
and breast-feeding
FDA category + note
Top interactionssee all 12 →
- AmprenavirSevereDatabaseDDInter
- ApalutamideSevereDatabaseDDInter
- AprepitantSevereDatabaseDDInter
- AtazanavirSevereDatabaseDDInter
Mechanism
Naloxegol is pegylated naloxone, which limits its penetration into the central nervous system (CNS). Its primary mechanism involves peripheral μ-opioid receptor antagonism. This action mitigates constipation by counteracting the opioid effect in the gut.
Indications
Opioid-induced constipation when response to other laxatives is inadequatePostoperative ileus following bowel resection surgeryOpioid-induced constipation (in adults)
Dosing
- Adult
- consistency. g In patients with hard stools, a high dose of an oral macrogol (such as macrogol 3350 with potassium chloride, sodium bicarbonate and sodium chloride) may be considered. In those with soft stools, or with hard stools after a few days treatment with a macrogol, an oral stimulant laxative should be started or added to the previous treatment.…
Pharmacokinetics
Peak effect
About 2 h, with a secondary peak 0.4 to 3 h after the first
Half-life
6–11 h (variable)
Metabolism
Primarily by hepatic CYP3A
Excretion
68% in feces, 16% in urine
Contraindications
- Concomitant administration with voriconazole (due to increased side effects of naloxegol)
- Known or suspected GI obstruction
Side effects
Common
DiarrheaAbdominal painFlatulenceNauseaVomiting
Serious
- Opioid withdrawal (may be precipitated in patients with a compromised blood-brain barrier)
Pregnancy & lactation
Pregnancy
and breast-feeding
Drug interactions
Apalutamide
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Aprepitant
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Atazanavir
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Berotralstat
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Boceprevir
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Carbamazepine
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Ceritinib
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Chloramphenicol
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Ciprofloxacin
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Clarithromycin
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Cobicistat
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Related guidelines
Irritable bowel syndrome
ISG · Gastroenterology · 2023
Inflammatory bowel disease
OTHER · Gastroenterology · 2015
Preoperative cardiac evaluation for non-cardiac surgery
AHA · Cardiology · 2025
Preventive care in inflammatory bowel disease
ACG · Gastroenterology · 2025
Substance use disorders
NIMHANS · Psychiatry · 2022
Other Antidote drugs
Ask House about Naloxegol
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: Goodman & Gilman 14e, BNF·Verified: 2026-05-13 · House clinical team