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Drug reference

Olodaterol

LABA · Agent for Obstructive Airway Diseases

Also known as Olodaterol hydrochloride

LABAAgent for Obstructive Airway DiseasesATC R03AC19
CDSCO approvedSchedule HATC R03AC19
EXCRETION
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
not curated
Top interactionssee all 12
  • MoclobemideSevereTextbookG&G 14e · p264
  • CarteololSevereDatabaseDDInter
  • CarvedilolSevereDatabaseDDInter
  • LabetalolSevereDatabaseDDInter

Mechanism

Olodaterol is an ultralong-acting beta-2 selective adrenergic agonist. It acts by stimulating beta-2 receptors in the bronchial smooth muscle. This stimulation leads to bronchodilation, thereby helping to improve airflow in patients with chronic obstructive pulmonary disease.

Indications

Maintenance treatment of chronic obstructive pulmonary diseaseCOPD

Dosing

Adult
5 micrograms once daily by inhalation, as part of a fixed-dose combination product (equivalent to 2 puffs of inhalation solution).
Max dose
5 micrograms once daily

Pharmacokinetics

Duration
Supports once-daily dosing

Side effects

Common
Muscle tremorTachycardiaPalpitations
Serious
  • Hypokalemia
  • Ventilation-perfusion (V/Q) mismatch (fall in arterial oxygen tension)
  • Metabolic effects (increase in free fatty acid, insulin, glucose, pyruvate, and lactate)
  • Life-threatening and fatal asthma exacerbations (if used alone in asthma)

Drug interactions

Moclobemide
Severe
Textbook

Increased risk of adverse cardiovascular effects.

At least 2 weeks should elapse between the use of MAO inhibitors and administration of β2 agonists or other sympathomimetics.

Source: G&G 14e · p264

Carteolol
Severe
Database

Drug interaction classified as: antagonism

Source: DDInter

Carvedilol
Severe
Database

Drug interaction classified as: antagonism

Source: DDInter

Labetalol
Severe
Database

Clinical effect not specified

Source: DDInter

Levobunolol
Severe
Database

Clinical effect not specified

Source: DDInter

Macimorelin
Severe
Database

Clinical effect not specified

Source: DDInter

Metipranolol
Severe
Database

Clinical effect not specified

Source: DDInter

Nadolol
Severe
Database

Clinical effect not specified

Source: DDInter

Ozanimod
Severe
Database

Clinical effect not specified

Source: DDInter

Penbutolol
Severe
Database

Clinical effect not specified

Source: DDInter

Pindolol
Severe
Database

Clinical effect not specified

Source: DDInter

Propranolol
Severe
Database

Clinical effect not specified

Source: DDInter

Related guidelines

Other LABA drugs

Ask House about Olodaterol

Continue into a citation-backed clinical answer with the drug context already attached.

Sources: Goodman & Gilman 14e, Katzung, BNF·Verified: 2026-05-10 · House clinical team