Drug reference

Prochlorperazine

Atypical Antipsychotic · Antipsychotic; Antiemetic

Atypical AntipsychoticAntipsychotic; AntiemeticATC N05AB04

CDSCO approvedSchedule HATC N05AB04

EXCRETION

—

not curated

INTERACTIONS

12 major

SEVERE in our sources

PREGNANCY

—

not curated

Top interactionssee all 12 →

Aminolevulinic AcidSevereDatabaseDDInter
AmiodaroneSevereDatabaseDDInter
AmisulprideSevereDatabaseDDInter
AnagrelideSevereDatabaseDDInter

Mechanism

First-generation antipsychotic drugs act predominantly by blocking dopamine D2 receptors in the brain. They are not selective for any of the four dopamine pathways in the brain.

Indications

Bipolar disorder and maniaPsychoses and schizophreniaNausea and vomitingGeneral-purpose antinauseant and antiemeticMotion sicknessNausea and vomiting of GI originviolent vertigoviolent vomitingvertigo associated vomitingchemotherapy induced nausea and vomiting (CINV, to some extent)postoperative nausea and vomiting (PONV)drug-induced vomitingdisease-induced vomiting (gastroenteritis, uraemia, liver disease, migraine)malignancy associated and mild chemotherapy-induced vomitingradiation sickness vomitingmorning sickness (only in hyperemesis gravidarum)Prevention of chemotherapy-induced nausea and vomiting

Dosing

Adult: equivalent doses of morphine p. 484 and diamorphine hydrochloride. Mixing and compatibility The general principle that injections should be given into separate sites (and should not be mixed) does not apply to the use of syringe drivers in palliative care. Provided that there is evidence of compatibility, selected injections can be mixed in syringe drivers.…

Contraindications

Subcutaneous infusion (due to skin reactions at the injection site)
Elderly patients with dementia-related psychosis (increased mortality)
should not be administered until the cause of vomiting has been diagnosed

Side effects

Common

Extrapyramidal symptomsElevated prolactinSedative effects (less pronounced than Group 1 phenothiazines)Antimuscarinic effects (less pronounced than Group 1 phenothiazines)Skin reactions at the injection site (if given subcutaneously)DystoniaCardiac effectsHypotension

Serious

Extrapyramidal reactions
Increased mortality in elderly patients with dementia-related psychosis
muscle dystonia
extrapyramidal side effects

Drug interactions

Aminolevulinic Acid

Severe

Database

Drug interaction classified as: synergy

Source: DDInter

Amiodarone

Severe

Database

Drug interaction classified as: synergy.

Source: DDInter

Amisulpride

Severe

Database

Drug interaction classified as: synergy

Source: DDInter

Anagrelide

Severe

Database

Drug interaction classified as: synergy

Source: DDInter

Arsenic Trioxide

Severe

Database

Drug interaction classified as: synergy

Source: DDInter

Bedaquiline

Severe

Database

Drug interaction classified as: synergy

Source: DDInter

Bepridil

Severe

Database

Drug interaction classified as: synergy

Source: DDInter

Buprenorphine

Severe

Database

Drug interaction classified as: synergy.

Source: DDInter

Bupropion

Severe

Database

Drug interaction classified as: metabolism.

Source: DDInter

Cabozantinib

Severe

Database

Drug interaction classified as: synergy

Source: DDInter

Central Nervous System Depressants (e.g., Opioids, Benzodiazepines, Alcohol, Antihistamines)

Severe

Database

Increased sedation, respiratory depression, hypotension, psychomotor impairment. Risk of falls and accidents.

Avoid concomitant use if possible. If co-administration is necessary, use the lowest effective doses of both drugs, monitor closely for CNS depression, and advise patients against driving or operating machinery.

Ceritinib

Severe

Database

Drug interaction classified as: synergy

Source: DDInter