Nitrous Acid
Severe
Database
Clinical effect not specified
Source: DDInter
Drug reference
Rasburicase
Antidote · Antihyperuricemic
AntidoteAntihyperuricemic
CDSCO approvedSchedule H
EXCRETION
—
not curated
INTERACTIONS
2 major
SEVERE in our sources
PREGNANCY
Manufacturer advises avoid—no information available.
FDA category + note
Top interactions
- Nitrous AcidSevereDatabaseDDInter
- PrilocaineSevereDatabaseDDInter
Mechanism
Rasburicase is a recombinant urate oxidase enzyme. It catalyzes the enzymatic oxidation of uric acid into allantoin, a more soluble and readily excretable inactive metabolite. This action rapidly reduces plasma-uric acid concentration.
Indications
Prophylaxis and treatment of acute hyperuricaemia, before and during initiation of chemotherapy, in patients with haematological malignancy and high tumour burden at risk of rapid lysisprevention and treatment of hyperuricemiaInitial management of elevated plasma uric acid levels in pediatric and adult patients with leukemia, lymphoma, and solid tumor malignancies who are receiving anticancer therapy expected to result in tumor lysis and significant hyperuricemia
Dosing
- Adult
- BY INTRAVENOUS INFUSION: 200 micrograms/kg once daily for up to 7 days according to plasma-uric acid concentration
Contraindications
- G6PD deficiency
- Atopic allergies
- Glucose-6-phosphate dehydrogenase deficiency
Side effects
Common
Diarrhoeafeverheadachenauseaskin reactionsvomitingAbdominal painConstipationDiarrheaMucositis
Serious
- Bronchospasm
- haemolysis
- haemolytic anaemia
- hypersensitivity
- hypotension
- methaemoglobinaemia
- seizure
- Muscle contractions involuntary
- hemolytic anemia
- methemoglobinemia
- Hemolysis in G6PD-deficient patients
- Acute renal failure
- Anaphylaxis
- Activity-limiting antibodies (limit use for chronic gout)
Pregnancy & lactation
Pregnancy
Manufacturer advises avoid—no information available.
Lactation
Manufacturer advises avoid—no information available.
Drug interactions
Prilocaine
Severe
Database
Clinical effect not specified
Source: DDInter
6 additional unreviewed or low-confidence interactions hidden because their provenance or source detail is insufficient.
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Textbook-sourced·Sources: Goodman & Gilman 14e, Harrison 22e, Katzung, BNF·Updated: 2026-05-10