Drug reference
rolofylline
Adenosine A1 receptor antagonist · Diuretic
Adenosine A1 receptor antagonistDiuretic
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
—
none in our sources
PREGNANCY
—
not curated
Mechanism
An A1 adenosine receptor antagonist, intended to inhibit tubular reabsorption of Na+ and water, dilate the afferent arteriole, and inhibit tubular-glomerular feedback.
Indications
acute heart failure with impaired kidney function (failed clinical trials)
Side effects
Serious
- seizures
Related guidelines
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Textbook-sourced·Sources: Goodman & Gilman 14e·Updated: 2026-05-10