Drug reference

Sodium citrate

Antidote · Laxative, Oral rehydration agent, Urinary alkalinizing agent (as component)

AntidoteLaxative, Oral rehydration agent, Urinary alkalinizing agent (as component)

CDSCO approved

EXCRETION

—

not curated

INTERACTIONS

1 major

SEVERE in our sources

PREGNANCY

—

not curated

Top interactions

Aluminum HydroxideSevereDatabaseDDInter

Mechanism

Sodium citrate acts as a calcium complexing agent, binding to calcium ions. In vitro, this property is utilized to prevent blood coagulation by chelating calcium, thereby keeping blood in a fluid state for transfusions and investigations. When used rectally as an enema, it functions as a laxative, though its specific mechanism for this use is not detailed in the provided text. As a component of oral rehydration therapy, it contributes to electrolyte balance.

Indications

Faecal impaction (rectal)Constipation (rectal)Relief of discomfort in mild urinary-tract infections (oral)Acute diarrhoea (as a component of oral rehydration therapy)Casual treatment of heartburn

Dosing

Adult: Rectal: 5-10 mL for 1 dose. Oral: Dose to consult product literature for relief of discomfort in mild urinary-tract infections.
Pediatric: Child 3-17 years: Rectal: 5-10 mL for 1 dose.