Sodium Thiosulfate

Sodium thiosulfate acts as a sulfur donor substrate for the mitochondrial enzyme rhodanese (thiosulfate sulfurtransferase), which converts highly toxic cyanide (CN⁻) to the relatively non-toxic thiocyanate (SCN⁻) that is excreted renally. This enzymatic detoxification pathway is the body's primary defense against cyanide poisoning, and exogenous thiosulfate administration accelerates the reaction beyond physiological capacity. It is also used to prevent cisplatin nephrotoxicity by binding to and inactivating cisplatin in the renal tubules.

Adult

12.5 g by intravenous injection over 10 minutes; dose may be repeated in severe cyanide poisoning. (12.5 g equates to 50 mL of a 25% solution or 25 mL of a 50% solution).

Pediatric

Child: Consult the National Poisons Information Service

• Other superficial mycosis