Spectinomycin

Spectinomycin is an aminocyclitol antibiotic (structurally related to but distinct from aminoglycosides — it lacks amino sugars) that binds to the 30S ribosomal subunit and inhibits translocation of the peptidyl-tRNA from the A site to the P site on the ribosome. Unlike true aminoglycosides, spectinomycin does not cause misreading of mRNA, its action is bacteriostatic rather than bactericidal, and it does not cause ototoxicity or nephrotoxicity. It was historically used as a single-dose treatment for gonorrhea.

Adult

weighs 70 kg (154 lb) and has an estimated creatinine clearance of 90 mL/min. How should tobramycin be dosed using once­daily and traditional dosing strategies? How should each regimen be monitored for efficacy and toxicity? The drugs described in this chapter are bactericidal inhibitors of protein synthesis that interfere with ribosomal function.* These agents are useful mainly against aerobic gr…